The coupling effect between stress and galvanic corrosion on bimetallic screws in the femoral environment was systematically investigated for the sake of providing a theoretical basis for the wear prevention and control of a novel degradable screw used in the treatment of vertical femoral neck fractures(Pauwels type III). A three-dimensional model of the femoral based on the CT data was created. With respect to the assembled screws, three geometric structures were proposed, and two sets of material properties, namely Ti/Mg (titanium/magnesium alloy) and Ti/Zn (titanium/zinc alloy) were assigned to afford different mechanical and electrochemical characteristics. Through a multi-physics finite element model, the electrochemical corrosion behaviors and stresses of the screws at different degrees were coupled and analyzed. The research results show that, in the 120-day corrosion process, the Ti/Zn composite screw had the maximum current density and maximum stress at the defect of 0.063 2 A/m² and 35 MPa, respectively, which are 94.18% and 86.06% less than those of the Ti/Mg composite (maximum current density at the defect of 1.083 A/m² and a stress of 251 MPa). An S_c/S_a of 0.43 had a significant effect on both single corrosion and load-bearing(the maximum current density and maximum stress of this type of screw in the Ti/Mg composite were 0.377 1 A/m² and 184 MPa, respectively), lower than that for S_c/S_a values of 3.34 and 1.11, by a significant margin. The stress concentration effect is higher than the yield point of the material (maximum stress of 251 MPa), through an interaction with corrosion, had a remarkable effect on which the material degradation was strongly accelerated(corresponding to an accelerated corrosion thickness of 53 μm). The coupling effect of galvanic corrosion and mechanical stress on the mechanical properties and corrosion resistance of bimetallic materials has a great influence. Optimizing factors such as the geometric structure of the S_c/S_a metal sleeve and the corrosion potential difference can improve the corrosion resistance and mechanical stability of the screw.