In order to deeply investigate the erosion characteristics of gas-solid two-phase flow in high-sulfur natural gas gathering and transportation pipelines, taking the actual production situation of the typical Puguang gas field in China as an example, the numerical coupling method of computational fluid dynamics ( CFD ) and discrete phase model ( DPM ) was used to study the distribution law of erosion wear of L360QS seamless elbow caused by sulfur particles during the transportation of sulfur-containing natural gas, with gas mass flow rate, operating pressure, temperature, elbow bending rate and sulfur particle size as five control variables. The results show that there is an exponential positive correlation between gas mass flow rate and erosion rate. When the mass flow rate of dry gas is greater than 15.36 kg/s, the sensitivity of erosion wear to gas mass flow rate is higher than that of bend curvature and particle size. When the operating pressure of gathering and transportation pipeline is 8~10 MPa, the sensitivity of gas viscosity to pressure is higher than that to temperature. When the pressure increases, the viscosity increases and the maximum erosion wear rate decreases. When the bending rate R/D≥ 2, the influence of elbow pressure loss on erosion tends to be stable. When the particle size is 10~50 μm, the maximum erosion area at the elbow is mainly distributed between 45.37° ~78.11° on the inner curved surface of the elbow. The results can provide reference for the safety design of sulfur-containing gathering pipeline, reducing erosion risk and prolonging service life.