In order to analyze the Mesozoic provenance periods in Liaohe depression, laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) was used to investigate zircon U-Pb dating of Mesozoic clastic rocks in Liaohe Depression. The results show that most of the zircons develop typical magmatic oscillatory ring structure and the Th/U >0.4, suggesting that they are magmatic zircons as a whole. Zircon ages are dominated by Mesozoic and Early Paleoproterozoic to Late Archean, followed by Paleozoic and Paleoproterozoic ages. However, there are differences in the composition of zircon ages in different regions. Damintun sag is mainly composed of five groups of ages, the western sag is mainly composed of four groups of ages, and the eastern sag is mainly composed of two groups of ages. It is concluded that the Mesozoic strata in Liaohe Depression are mainly provided by the Mesozoic and Early Paleoproterozoic to Late Archaean parent rocks, which correspond to the subduction of the North China Plate by the Pacific Plate during the Yanshanian, the accompanying magmatic activities and the thermal events caused by the underplating of mantle plumes from late Archaean to early Paleoproterozoic. Next are the Paleozoic and Paleoproterozoic provenance, corresponding to a series of volcanic activities on the northern margin of the North China Plate during the Paleozoic and rifting during the early Paleoproterozoic. However, the provenance composition in different sags is different, and the type and supply intensity of parent rock are also different. The main age of zircon in this test is consistent with the time of multiple volcanic activities in the North China Plate, which may be the main source of the study area. The provenance composition of Mesozoic clastic rocks in Liaohe Depression is identified, which is of great significance for further analysis of provenance system in Liaohe Depression, constraint of stratigraphic age and magmatic activity in the study area.