In the blasting engineering of large section tunnel, the blasting effect is closely related to the existence of ground stress. The high ground stress environment has a significant influence on the surrounding rock pressure, deformation and stability of deep buried tunnel. In order to explore the dynamic response of the ground stress to the rock mass near the tunnel and the damage evolution distribution of the tunnel face during the blasting of the large section tunnel, the constitutive model was established by the large-scale finite element simulation software ANSYS / LS-DYNA, and the numerical calculations were performed for four working conditions of no ground stress and three different ground stresses. The results show that the peak values of effective stress and vibration velocity at the vault position are the largest under different working conditions, indicating that the vault is the most dangerous position of the tunnel excavation face. When there is no ground stress, the damage depth in the middle of the floor is the largest, which is 3.84 cm. The ground stress inhibits the blasting effect to a certain extent.