The voltage fluctuations in the high-voltage DC bus of the train traction converter have a significant impact on the output power quality of the traction system. Therefore, it is necessary to improve the response speed of the intermediate stage isolated DC/DC converter to reduce the power coupling between the high-voltage stage and the low-voltage stage. Taking the isolated DC/DC converter as the research object, an unbiased model predictive control and sampling noise suppression strategy was proposed to address its inherent problems of high sensitivity to circuit parameters and susceptibility to sampling noise. Firstly, the operation principle of the dual-bridge series resonant converter and the causes of the steady-state errors were analyzed, and a feedback correction method based on recursive least square algorithm was designed to eliminate the steady-state error. Then, the introduction of noise suppression coefficient reduces the sensitivity of the control variable to the control target through a simple and effective method. Furthermore, the virtual current was utilized in predictive model instead of the actual current sampling value, and it further reduces the system costs. Finally, an experimental platform was built to verify the improvement of the proposed strategy in both steady-state and dynamic performance.