In order to explore the potential molecular mechanism of Xiangsha Liujunzi Decoction in intervening hyperlipidaemia, the chemically active ingredients and targets of Xiangsha Liujunzi Decoction was collected using TCMSP (traditional Chinese medicine systemic pharmacology platform) by applying network pharmacology and molecular docking technology, and then the "ingredient-target" network was established through the protein database and String database. Based on the targets obtained from screening, the association analysis of hyperlipidaemia, a disease treated by Xiangsha Liujunzi Decoction, was carried out to establish a "target-disease" network; Subsequently, GO(gene ontology analysis), KEGG (kyoto encyclopedia of genes and genomes) and PPI(protein-protein Interaction networks) enrichment analysis was carried out to obtain the key pathways of Xiangsha Liujunzi Decoctionin the treatment of the disease; and the obtained components and targets were subjected to molecular docking, which resulted in the establishment of a 'target-disease' network. The obtained components and targets were subjected to molecular docking to comprehensively explore the complex action network of Xiangsha Liujunzi Decoction in the treatment of hyperlipidaemia in clinical practice. The results show that the mechanism of Xiangsha Liujunzi Decoction in preventing hyperlipidaemia is mainly related to the AGE-RAGE(advanced glycation endproducts-receptor for advanced glycation endproducts) signalling pathway, shear stress and AS(atherosclerosis) pathway, TNF(Tumor necrosis factor) pathway and apoptosis pathway, and that the effector components of Xiangsha Liujunzi Decoction has a better binding to the core targets of hyperlipidaemia, such as baicalein-ALOX12 and chuanchengpiin-ALOX12, which show that Xiangsha Liujunzi Decoction, as a classical Chinese medicine formula, has a good ability to strengthen the spleen and lower the blood pressure, and it is also a good choice for the treatment of hypertension. It can be seen that Xiangsha Liujunzi Decoction, as a classic traditional Chinese medicine formula, has good efficacy in strengthening the spleen and lowering lipids, and it is of great significance to investigate its mechanism of action in the treatment of hyperlipidaemia.