The content of radioactive nuclides, such as uranium (²³⁸ U), radium (²²⁶ Ra), and potassium (⁴⁰ K), in geothermal waters determines the classification and use of therapeutic thermal mineral waters. To investigate the precipitation characteristics of uranium, radium, and potassium in the surrounding rock medium, static laboratory experiments were conducted using Cambrian limestone as the medium. The effects of different temperatures and durations on the precipitation of these elements were analyzed. The results show that temperature is a significant factor influencing the release of radioactive nuclides ²³⁸U, ²²⁶Ra, and ⁴⁰K. As the temperature increases, the concentrations of radioactive nuclides in the water increase significantly. The soaking time has little effect on the release of ⁴⁰K but significantly influences ²³⁸U, which undergoes rapid and slow release phases. The release rate of ²²⁶Ra is closely related to the initial concentration of the element; the higher the concentration, the faster the release. The experiment also found that the increase of Ca²⁺ and promoted the precipitation of ²²⁶Ra, while Cl^- favored the precipitation of ²³⁸U. The increase in total dissolved solids (TDS) and conductivity facilitated the precipitation of uranium, radium, and potassium, while changes in pH may limit their precipitation.