In order to alleviate the transport pressure of road and railway traffic, cope with the energy crisis, and reduce carbon emissions in transport, research has been conducted on a new energy-saving and efficient transportation method called pressurized pipeline hydraulic transportation wheel carrier capsule (referred to as capsule transportation). The effects of wheeled capsule structural parameters and Reynolds number on the capsule followness were investigated by physical modeling tests on flat slopes and uphill and downhill pipelines. The results show that with constant capsule structural parameters, the follower rate increases with increasing Reynolds number in uphill, flat and downhill pipelines, and the follower rate reaches a peak when the Reynolds number is 6 192, and then the follower rate gradually decreases with increasing Reynolds number. Capsule follower rate with the Reynolds number, the relative diameter of the capsule, the relative length of the capsule and the capsule weight show a trend of increasing and then decreasing, and there is a peak. When the capsule weight is equal to 0, the capsule follower rate is basically the same on the flat slope, the uphill and the downhill, due to the rolling friction generated by the moment of the force coupling has a smaller impact on the follower rate. When the weight of the capsule is less than 0, the follower rate is the same on the flat slope, the uphill and the downhill pipeline. When the capsule counterweight is less than 0, the follower rate in the flat slope, uphill and downhill pipeline is: uphill > flat slope > downhill. When the capsule counterweight is greater than 0, the follower rate in the flat slope, uphill and downhill pipeline is: downhill > flat slope > uphill. The results of the study can provide a reference for the optimization and efficient operation of the structure of wheeled carrier capsule for hydraulic transportation of pressurized pipelines.