In order to study the influence mechanism of energetic particles on the combustion and explosion reaction of solid-liquid mixed fuel, a 20 L spherical cloud combustion and explosion characteristics test system was used to study the combustion and explosion characteristics of solid-liquid fuel-air dispersion systems with different mass fractions of energetic substances. Under low concentration conditions, the explosion pressure, maximum pressure rise rate, reaction time and explosion lower limit of different fuels were measured. Based on the combination of solid-liquid dispersed particles, the impact of energetic particles on the combustion and explosion characteristics of solid-liquid mixed fuel was analyzed. The results show that in the 1,3,5-trinitroperhy-dro-1,3,5-triazine(RDX)/aluminum powder mixed fuel system, the explosion pressure and maximum pressure rise rate first increase and then decrease with the increase of RDX mass fraction, with the maximum values being 1 516.17 kPa and 116.17 kPa/ms respectively. For RDX/ aluminum powder/nitromethane mixed fuel system, the addition of RDX causes the explosion pressure to continuously decrease, reaching 427.99 kPa. When the RDX mass fraction is low, RDX inhibits the combustion explosion of the mixed fuel. At the same time, it was found that the change pattern of mixed fuel reaction time is completely opposite to the change pattern of maximum pressure rise rate.