Buried pipeline is an important part of oil and gas transportation. The subsidence of gob area will cause the corresponding subsidence of the pipeline passing through the gob area, resulting in pipeline deformation, fracture and other accidents. Taking Puxian-Hejin pipeline crossing coal mining subsidence area as the research background, 3D printing technology was used to make up for the mismatch in mechanical similarity between pipeline simulation materials and geotechnical simulation materials, and the coupling simulation experiment between pipeline and rock and soil was constructed. The mining response of buried pipeline caused by coal mining was analyzed, and the correlation between pipeline movement deformation and stratum movement deformation was established. The research shows that the buried pipeline and the underlying rock strata do not synchronously settlement, resulting in delamination between the overlying rock strata and the underlying rock strata. The pipeline bends and deforms under the overlying rock load and its own weight. When the delamination span is large enough, the bending tensile stress on the bottom of the pipeline exceeds the allowable stress, resulting in tensile failure. The subsidence value of the buried pipeline is about 1.21 times of the formation subsidence value, and only 18% of the horizontal deformation of the formation is transmitted to the pipeline. The research results have guiding significance for the safe laying and daily maintenance of pipelines in subsidence area.