In order to study the effect of different scanning strategies on laser deposition of nickel-based alloy matrix, the process of deposition of IN718 alloy powder on IN718 alloy matrix under four different scanning strategies was numerically simulated by ABAQUS software, and tested under the same conditions. The heat source verification results show that the heat source model is accurate and effective, and the numerical simulation process accords with the actual deposition process. The analysis results of temperature field, stress field and deformation field show that the thermal influence of different side scanning is less than that of same side scanning and reciprocating scanning is lower than that of unidirectional scanning, and the peak temperature is lower, thus the residual stress is lower, and the deformation degree of the matrix can be effectively reduced. The experimental results show that the numerical simulation process is accurate and effective. It is concluded that the residual stress value and deformation can be reduced effectively by using the reciprocating scanning method on different sides.