The small pore throat radius, high starting pressure gradient, poor formation physical property and large gas production difference of horizontal wells after fracturing in tight sandstone reservoirs seriously affect the increase of tight gas reserves and production. In view of the above problems, the production dynamics of gas wells under different levels of sweet spots in the eastern Ordos Basin were analyzed, and a new tight gas fracturing method based on sweet spot distribution was proposed. Based on the evaluation of rock mechanics parameters, energy storage coefficient and argillaceous content parameters, the evaluation model of geological sweet spot and engineering sweet spot was established, and the reservoir quality of tight sandstone gas reservoir was divided by fuzzy comprehensive evaluation method. According to different sweet spot types, the production characteristics and sweet spot distribution characteristics of Class Ⅰ, Ⅱ and Ⅲ horizontal wells were summarized, and three fracturing modes based on geological sweet spot and engineering sweet spot were formed. The results show that when the horizontal well is drilled in Class I geological sweet spot and Class I engineering sweet spot, the cumulative gas production is higher than expected (Class I well), and a larger fracturing scale and displacement can be adopted to maximize the economic benefit (Model 1). When the horizontal well is drilled in Class I geological sweet spot and Class Ⅱ engineering sweet spot combination, the cumulative gas production is lower than Class I well (Class Ⅱ well), and the fracturing scale should be reduced appropriately to pursue a certain production capacity and economic benefit (Model 2). When horizontal wells are drilled in geological sweet spots below Class Ⅱ and combinations of Class Ⅰ/Ⅱengineering sweet spots, the production effect is the worst (Class III wells), and the fracturing scale should be controlled by reducing displacement to avoid the fracture from entering the risk layer and obtain a certain production rate (Model 3). The above new fracturing method was applied to a newly drilled horizontal well in a tight gas reservoir, and the open flow and gas production of the horizontal well after fracturing reached the expectation, which has certain guiding significance for the development of tight sandstone gas reservoir.