The occurrence characteristics and genetic models of geothermal resources is an important basis for the development of geothermal resources. Drilling data, geophysical and geochemical data was applied to analyze the thermal reservoir, cap rock, heat sources, channels and supply elements, and the genetic model of geothermal system in the southwest of Zhoukou Depression was established. The development prospect was also evaluated. The geothermal resources in study area can be divided into sedimentation basin type with low temperature. Mantle derived heat is the main heat source, and the geothermal flow in the north part is higher than that in the south part, also in the protruding area is higher than that in the depressed area, reaching over 70 mW/m². The average geothermal gradient is about 2.8 ℃/hm, dominated by heat conduction system. Isotope analysis shows that the supply source comes from atmospheric precipitation in the western low mountains and hills, which infiltrates through the exposed area and moves along permeable strata and unconformity towards the east, and is heated and warmed up. The pores of the Neogene and Paleogene sandstones, as well as the karst pores of the Cambrian-Ordovician carbonate rocks, are the main storage spaces for fluids. The silt and clay deposits developed in the upper part of the Quaternary and Neogene systems form a good waterproof and thermal insulation cover layer. The development and utilization risk of the Neogene system is the lowest, with a floor depth of 400 ~ 1 400 m, increasing towards the north. The average sand to soil ratio is 40.9%, with a water flow between 40 ~ 60 m³/h and a wellhead temperature of 43 ~ 48 ℃. The development of faults also promotes the upwelling of deep heat flow, and there is a local thermal convection warming effect. Finally, four favorable development area for porous geothermal resources and three favorable areas for karst resources were identified.