In order to study the stability of the tunnel structure under the airport runway when the aircraft is running, the numerical calculation model of the runway, soil layer and tunnel structure co-deformation was constructed by establishing the six-degree-of-freedom dynamic equation of the "five-point contact" aircraft. The influence of the aircraft type, pavement type and buried depth on the stability of the tunnel structure was analyzed. The results show that the more concentrated the distribution position of the main landing gear wheel is, the greater the influence on the stability of the tunnel structure under different aircraft loads. The attenuation effect of stress diffusion on the flexible tunnel surface is obviously better than that on the rigid tunnel surface, and the deformation degree of the arch top is more significant than other locations. With the increase of the buried depth of the tunnel structure, the disturbance effect of aircraft load on the tunnel structure shows a decreasing trend. When the buried depth of the tunnel structure exceeds 64 m, the tunnel structure no longer bears the disturbance effect of aircraft load.