With the development of global trade, buoyancy-lifting hybrid airship is an important choice for global long-distance and large-load transportation, it has gradually become a research hotspot at home and abroad. In order to improve the transportation efficiency of buoyancy-lifting hybrid airship, its layout and parameter sensitivity were studied. Discussions were conducted on the hull layout and tail wing layout, and several types of hull and tail wing layouts with high lift to drag ratios were proposed. At the same time, a sensitivity analysis was conducted on the impact of design parameters on aerodynamic characteristics. The results indicate that the width of the hull has the most significant impact on the lift coefficient, drag coefficient, and maximum lift to drag ratio of airships. Its relative sensitivity coefficient is nearly ten times that of the longitudinal position and inclination angle of the tail wing. The inclination angle of the tail wing has the strongest impact on the torque coefficient of the airship, and its relative sensitivity coefficient is more than twice the width of the hull.