In order to solve the problem that the synchronous control accuracy of the climbing frame with multi-node structure is susceptible to external disturbance during operation, a deviation coupling control method based on sliding mode variable structure was proposed. Secondly, the fuzzy PID (proportion integral differential) control algorithm was used to improve the control accuracy of deviation coupling, and a fuzzy sliding mode displacement controller was designed to eliminate jitter by combining fuzzy control and sliding mode control, so as to improve the synchronous control performance between nodes. Finally, MATLAB/Simulink was used for simulation and experimental verification. Simulation and experimental results show that compared with the traditional deviation coupling structure, the errors between nodes in the proposed method are reduced by 68.2%, 73.5% and 78.2% respectively under the condition of interference, which has better synchronization accuracy and good robustness.