In order to solve the technical problem of insufficient reliability and life of rotary seal under the coupling effect of high pressure and high speed and medium corrosion, experimental research on rotary lip seal was carried out, a high-speed rotary lip seal test bed with pressure was designed and built, leakage and friction torque characteristic tests of lip seal were carried out, simulation calculation of lip seal was carried out, and a new type of seal with low friction coating was innovatively proposed. The temperature rise and torque comparison test of traditional seal and spraying new seal at different speeds were carried out. The experimental results show that the lip spraying tetrafluoroethylene (PTFE) material can effectively reduce the temperature rise of the seal. When the rotational speed increases by 1 000 r/min, after reaching the heat balance temperature, the temperature rise of the spray lip seal is 2.4 ℃ lower than that of the traditional lip seal. Under the pressure condition, the temperature of the coated lip seal is about 3.48 ℃ lower than that of the traditional lip seal. Under the condition of high speed and poor lubrication, the temperature of the spray lip seal is about 4.61 ℃ lower than that of the traditional lip seal, but the sealing torque increases by about 0.03 N·m. The sealing performance is evaluated from two aspects of sealing temperature rise and sealing friction torque, which provides theoretical support for solving the technical problems of high parameter rotary seal.