The current seismic toughness assessment is mainly aimed at the impact of a single earthquake on a single building, it is difficult to consider the seismic toughness assessment of different buildings in the same area. The research area was divided into grids according to 500 m × 500 m, and seismic risk analysis was carried out. Six indexes, including the cost of building defense, damaged area of different degrees, direct economic loss of buildings, repair time, repair cost and casualties, were taken as the evaluation indexes of earthquake resilience. Analytic hierarchy process (AHP) was used to determine the weights of each index, and an earthquake resilience evaluation model based on grid and radar map was established and applied to Chengdu City. The results show that the earthquake toughness of Chengdu City is normal when the fortification is not upgraded. After upgrading the fortification, the cost of fortification increases by 45.95%, and the damaged area, the direct economic loss of the house, the repair time, the repair cost and the number of casualties decreases by 26.25%, 37.75%, 45.1%, 44.24% and 48.18%, respectively. Through comparative analysis of the model data, it is found that after upgrading the fortification, the comprehensive benefit of earthquake resilience of Chengdu City buildings is increased by 40.8%, the disaster loss is greatly reduced, and the improvement effect is obvious.