To investigate the correlation between aerobic exercise and cardiac function, lipid metabolism, and inflammation in patients with cardiovascular disease, by searching PubMed, Embase, Scopus, and China National Knowledge Infrastructure (CNKI) databases for relevant studies on the effects of aerobic exercise on cardiac function, lipid metabolism, and inflammatory factors in patients with cardiovascular disease, Meta-analysis and correlation analysis were conducted using RevMan5.4 and R software. The results show that aerobic exercise significantly reduces B-type natriuretic peptide (BNP) [SMD = -0.84, 95% CI (-1.34, -0.34), P=0.001], systolic blood pressure (SBP) [SMD = -0.55, 95% CI (-0.86, -0.25), P=0.000 4], and diastolic blood pressure(DBP) [SMD = -0.99, 95% CI (-1.67, -0.32), P=0.004], LDL [SMD = -0.53, 95% CI (-0.89, -0.18), P=0.003], and C-reactive protein (CRP) [SMD = -0.53, 95% CI (-0.90, -0.16), P=0.005]. CRP is positively correlated with HDL, LDL, and DBP, with correlation coefficients of 0.35, 0.26, and 0.28, respectively. CRP is negatively correlated with SBP, with correlation coefficients of -0.31. From this, it can be seen that aerobic exercise can improve heart function, lipid metabolism, and levels of inflammatory factors to a certain extent in patients with cardiovascular diseases, and there is a correlation between heart function, lipid metabolism, and inflammation.