Field practice has shown that the micro permeability law of low-permeability tight oil reservoirs has a significant impact on the early productivity of oil wells. Basing on the micro permeability experimental results and dynamic-static parameters of nearly 60 cores from nearly 10 tight oil blocks in Huawa and Yonglian zones of Jiangsu Oilfield, the reservoir characteristics of the target block were analyzed and evaluated. Corresponding seepage models and two-phase flow productivity equation were constructed. Through the analysis of the influence degree of single factor and multi-factor superposition on productivity, the main controlling factors affecting the early reasonable productivity of the target block and the sensitivity of the influence on productivity were clarified. The results indicate these as follows when considering the influence of single factors, the starting pressure gradient and water production rate have a significant impact on tight oil development. When considering the superposition effect of multiple factors, the productivity of typical wells decreases by up to 89.25%. The research results can provide a reasonable basis for improving the the seepage mode and reasonable production allocation, contributing to effectively develop low permeability tight reservoirs.