The Heijianshan granodiorite is located in the Xiao Requanzi-Dananhu Paleozoic residual arc of the Late Paleozoic arcbasin system in the eastern Tianshan orogenic belt. Clues from fieldwork, petrography, geochemistry and Zircon U-Pb geochronology were integrated to provide constraints on the tectonic setting in the Late Devonian. Geochemistry data shows that the granitic amphibolite is a set of type I granite with the characteristics of high silica, quasi-aluminous, and medium-high potassium-calcium alkalinity. The total amount of rare earth elements varies from 112.82 × 10 ^-6 to 129.91 × 10 ^-6, and the light/heavy rare earth ratio varies from 8.73 to 11.26 (mean value 9.64). Eu elements show weakly negative anomalies (δEu = 0.77 ~ 0.85). The sample is enriched in large ion lithophile element (LILE, e. g. , Rb, Ba, K, U), lacking high-field strength elements (HFSE, e. g. , Ta, Nb, and Ti) and P, with significant negative anomalies in Nb and Ta. It shows the characteristics of island arc magmatic rocks. The inductively coupled plasma mass spectrometry(LA-ICP-MS) zircon U-Pb isotope dating results show that the weighted average ages of granitic amphibolites in the area are (373.0 ± 3.0) Ma, indicating that the granodiorites were formed during the Late Devonian, and are contemporaneous products of large-scale Late Paleozoic medium-acidic magmatic intrusion in the Xiao Requanzi-Da Nanhu island arc of the east Tianshan Block. The combination of regional geological features, petrography and magma source area characteristics suggests that the Late Devonian granodiorite in the Heijinshan area of the east Tianshan block is a product of the island-arc of the northward subduction of the ancient oceanic plate.