In September 5, 2022, a M6.8 earthquake occurred in Luding County Sichuan Province. Quite a lot of store-front type buildings damaged or collapsed. Five representative buildings representing both positive and negative aspects were selected to analyze the earthquake damage mechanism through theoretical basis and model experiment. The results show that the earthquake damage is mainly concentrated in the bottom layer, which is composed of concrete column and masonry wall. The masonry wall with no lateral openings restrains the transverse and torsional deformation of the structure, and the floor only transports along the longitudinal direction, and the seismic shear force shared by each member is proportional to its longitudinal lateral stiffness. The rigid and brittle members with large stiffness will appear "internal force condensation", and then reach "deformation saturation", and lose the load-bearing capacity in the way of brittle failure, and the gravity of the upper layers will be borne by the transverse wall. If the earthquake does not stop at this time, the transverse wall will lose the role of "buttress" in the direction of exit plane, and the whole structure will collapse along the longitudinal contact with the ground. On the contrary, if the structure of the bottom layer avoids large differences in stiffness, it can significantly improve the seismic resistance.