Cable-stayed oil and gas pipeline bridges are characterized by low lateral stiffness and complex vibration characteristics. Therefore, serious coupling damage may occur in earthquakes, affecting the safety of oil and gas transportation pipelines and their cable-stayed pipe bridge structures. Focusing on the intelligent vibration damping control of oil and gas transportation cable-stayed pipe bridge structure, a new type of piezoelectric variable friction damper was developed, the output force performance test was carried out, and the semi-active vibration damping control strategy of cable-stayed oil and gas pipe bridge was proposed. Based on the engineering examples, a structural calculation model of the cable-stayed pipe bridge was established, the specific path of the implementation of the vibration damping control strategy was explored, and the effect of piezoelectric intelligent semi-active vibration damping control of the cable-stayed oil and gas pipe bridge structure was analyzed. The results show that the output force of piezoelectric variable friction damper shows a good linear relationship with the driving voltage, and the established driving voltage-damping force eigenstructure model can be used for the seismic control of cable-stayed pipe bridge structure, and The proposed LQR-Bang-Bang semi-active intelligent control method and the developed piezoelectric variable friction damper can efficiently achieve the purpose of controlling the seismic response of the cable-stayed pipe bridge structure, and a better control effect has been achieved. And it can be used as a reference for the seismic design of this kind of cable-stayed oil and gas pipeline bridge.