Commercial vehicles will generate a large pitch angle when passing through impact conditions such as deceleration strips and pits. In this case, the damping should be controlled taking a different control strategy from that in the running process on a normal road surface. A hybrid control strategy was proposed firstly, which integrated improved sky-hook control with improved single-sensor control and could adjust the weights of different algorithms according to such information as pavement conditions and vehicle state. Then, the parameters of each controller were determined through real vehicle data. Meanwhile, some control strategies were verified in real vehicles. The results reveal that the proposed control strategy could effectively enhance the riding comfort of vehicles. Subsequently, different road impacts were simulated on a 1/2 half-vehicle model. The results reflect that the proposed strategy achieved favorable optimization effects on reducing the sprung mass acceleration and pitch angle acceleration and exhibited a good control effect within the whole frequency domain.