Loading coagulation with sand has been widely used to efficiently treat mine water with high suspended solids by coagulation. However, few systematic studies on the effect of hydrochemistry characteristics on coagulation treatment of high suspended mine drainage. Therefore, the typical high suspended mine water was selected to analyze the effect of pH, Ca²⁺, TDS (total dissolved solids) and emulsion oil on the efficiency of high suspended matter mine water treated by loading coagulation treatment with sand. The results show that lower and higher pH value are not helpful for the efficiency of loading coagulation treatment with sand. When pH is 9.00, the rate and efficiency of loading coagulation treatment are the highest. Meanwhile, the increase of Ca²⁺ content and the decrease of emulsified oil content can promote the efficiency of loading coagulation treatment. Whereas, the TDS content and hydrochemical type effect can be ignored. The results can effectively improve the operation technology of the loading coagulation with sand, realize the protection and rationalization of coal mine water resources.