In order to solve the problem of node voltage fluctuation when high proportion of distributed power was connected to the distribution network, an active and reactive power cooperative optimal control strategy considering intelligent soft switch were presentsd. Firstly, the factors affecting the voltage fluctuation of nodes were analyzed, and the voltage can be controlled from the angle of active power and reactive power, and the working principle of intelligent soft switch was analyzed. It can precisely control the active power transmitted between the feeder lines connected on both sides and provide a certain reactive power. Secondly, a mathematical model of active and reactive power optimization of distribution network with minimum loss and minimum voltage deviation as objective functions was established, which is transformed into a single objective model by weight coefficient. Thirdly, the model was solved by improving the grey wolf algorithm. Finally, the simulation verification was carried out on the IEEE33 node system. The results show that the proposed strategy can reduce the voltage fluctuation and network loss effectively.