The preparation process of Fructus choerospondiatis-Nutmeg tablets was discussed and its quality was investigated. Based on the requirements of tablets in the Chinese Pharmacopoeia (2020 edition), the appearance, hardness, disintegration time, weight difference and brittleness of the tablets were investigated, and the contents of four antioxidant components in Fructus choerospondiatis-Nutmeg tablets were determined by high performance liquid chromatography. The results show that the tablets are smooth in appearance, uniform in color, with hardness values in the range of 30 ~ 40 N, disintegration time controlled within 10 min, and the degree of brittleness less than 1%. Quercetin, protocatechuic acid, methyl eugenol, and myristyl ether show good linear relationships within 0.16 ~ 0.8 μg/mL (r=0.999), 4 ~ 20 μg/mL (r=0.999), 8 ~ 40 μg/mL (r=0.999), and 100 ~ 500 μg/mL (r=0.999), with average recoveries of 99.3%, 101.6%, 100.3%, and 99.3%, respectively. The relative standard deviation (RSD) values of precision, stability and reproducibility tests under methodological validation do not exceed 2%. The content determination method is simple, proprietary, accurate and reliable, and can be used as a reference for the quality standard of the compound Mongolian medicine Fructus choerospondiatis-Nutmeg tablets.