The Yili and Tuha Basins on the Tianshan Orogenic belt are important sandstone type uranium mineral areas in China. The Baxiankou area located in the Tuha Basin is an important area for uranium exploration in recent years, but uranium mineralization here is characterized by narrow ore belts, small thickness, low grade, and high calcium content. The study of trace element geochemical changes in Baxiankou area is weak, which restricts the analysis of the genesis of mineralization scale. Based on the study of the spatial zoning of oxidation fluid alteration, the quantitative migration and enrichment of trace element distribution patterns and characteristic elements in different alteration zones were carried out. Through comparison with the Mengqigur deposit in Yili Basin, the enrichment process and origin of uranium enrichment scale under the action of oxidation fluid in the Baxiankou area were revealed. The results show that the synchronous enrichment of variable valence elements such as U and Re within the mineralization zone indicates that oxidation-reduction is the main mineralization process. The enrichment of non volatile elements such as Sc, Co, Ni, Th, and REE in the oxidation zone and the depletion in the ore zone are related to the properties of groundwater. The hydrolysis and clay formation caused by high salinity groundwater enhance the adsorption of ions in the solution by debris particles in the oxidation zone. Since Pliocene, the rapid uplift of Tianshan Mountains caused the extreme arid climate in Tuha Basin, resulting in the redistribution of trace elements and rare earth elements in different alteration zones. In the analysis of the genesis of uranium mineralization, it is necessary to strengthen the characterization of the changes in valence and constant valence elements, and pay more attention to the ancient climate during the infiltration stage of the oxidation zone during the ore exploration process.