To analyze the medication regularity and mechanism of patented Chinese herbal compounds in treating hepatic fibrosis by using the methods of data mining and network pharmacology. The patent compounds of traditional Chinese medicine for the treatment of hepatic fibrosis in the China Patent Announcement Network of the State Intellectual Property Office was searched, and the database was established after screening and sorting. Microsoft Excel software and traditional Chinese medicine inheritance platform were used to conduct data mining and analysis on the medication rules of traditional Chinese medicine compound. To explore the mechanism of core high-frequency drug pairs in the treatment of hepatic fibrosis by network pharmacology. Finally, 147 patent compounds were selected for the treatment of liver fibrosis, involving 431 kinds of traditional Chinese medicine. There are Huangqi, Danshen, Biejia, Danggui and other high frequency Chinese medicine. The main effect of these drugs is to replenish deficiency, promote blood stasis and clear heat. Huangqi-Danshen is core high-frequency drug pair that treat hepatic fibrosis through active ingredients such as quercetin, luteolin, kaempferol and tanshinone IIA. myelocytomatosis viral oncogene (MYC), signal transducer and activator of transcription 3 (STAT3), serine/threonine kinase 1 (AKT1), estrogen receptor 1 (ESR1), FOS proto-oncogene (FOS), hypoxia-inducible factor 1 alpha (HIF1A), tumor protein p53 (TP53) and mitogen-activated protein kinase14 (MAPK14) are major therapeutic targets. It mainly involves phosphatidylinositol-3-kinase (PI3K)-protein kinase B (Akt), advanced glycation end products-receptor for advanced glycation end products (AGE-RAGE), tumor necrosis factor (TNF), interleukin-17 (IL-17), hypoxia-inducible factor-1 (HIF-1) and helper T cells 17 (Th17) cell differentiation signaling pathways. The results show that the patented Chinese herbal compounds for the treatment of hepatic fibrosis are mainly tonic drugs, blood-activating and stasis-resolving drugs and heat-clearing drugs. Huangqi-Danshen is used to treat hepatic fibrosis by regulating PI3K-Akt, AGE-RAGE, TNF, IL-17 and other signaling pathways with multi-component and multi-target.