Inorder to document the advanced knee osteoarthritis patients with night pain and depressive disorder undergoing TKA (total knee artarthroplasty) and to determine whether the specific coexisting pain and/or disorder at the time of TKA adversely affected postoperative outcomes. Retrospective evaluation was used to investigate 195 patients undergoing TKA from January 2018 to June 2020 in the fifth orthopedic department of Handan Central Hospital. The patients were divided into night pain group (Group A)/non-night pain group (Group B) and depressed disorder group (Group C)/non-depressed disorder group (Group D) seperatly, preoperative and postoperative 6 weeks, 3 months, 1 year the prevalence of night pain, volume of pain, the prevalence of depressive disorder were examined in subgroup analyses, valued the function of knee and quality of life. The valume of night pain were analysised by visual analog scale (VAS) and depressive disorder using CESD (center for epidemiological studies depression scale). In addition, WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) and 12-item short form survey (SF-12) scores were assessed for knee function and life qualities. The results show that 63.6% of patients reported night pain, and the prevalences of depressive disorder was 17.9%, preoperatively, respectively. Preoperatively, compared with Group B, those with night pain (Group A) had significantly poorer preoperative WOMAC scores, but no significant difference was seen between groups 1 year after TKA. Preoperatively, the WOMAC, SF-12 scores of patients with depressive disorder (Group C) were significantly poorer than those of without depressive disorder (Group D), and there was no difference in clinical outcome scores 1 year after TKA between these groups. This study revealed a considerable prevalence of night painand depressive disorder in patients undergoing TKA and that patients with these specific conditions reported poorer functional and quality of life scores preoperatively. It is concluded that TKA can provide satisfactory outcomes for patients with these specific conditions.