Considering the structural damage of the jammer projectile chamber during the launch of the jammer projectile, the loading condition and dynamic response of the jammer projectile chamber webs were analyzed. The shock wave loading and the response of metal web plate during the launch of the jammer projectile were tested, and the numerical simulation results are in good agreement with the experimental results, furthermore, the maximum dynamic response of the actual jammer projectile chamber under the shock wave was obtained. Based on the fluctuating pressure Spectral density loads obtained from the unsteady flow field simulation of the jammer projectile chamber cavity structure, the stress RMS (root mean square) values of the jammer projectile chamber under the fluctuating pressure of different aircraft conditions were calculated. The results show that the fluctuating pressure caused by the cavity structure of the jammer projectile chamber is the main reason for the structural damage of the jammer projectile chamber. According to the analysis results, some suggestions for improving the structure of the jammer projectile chamber are given.