Isothermal adsorption experiments are widely used in the field of geology as a research method to investigate the adsorption behavior between gases in coal seams. Taking the coal reservoirs of No. 13 Coal from Liuzhuang Mine as the research object, N₂ and CO₂ gas adsorption experiments were carried, and the optimal adsorption model for gas adsorption in low permeability coal was selected on the basis of a comprehensive analysis of the squared regression coefficients of the fit R², the residual sum of squares of the calculated and experimental values of the model v, and the relative errors s. The results show that the models fitting degree of N₂ adsorption in low permeability coal from high to low: optimized L model > optimized D-A model > optimized D-R model> D-A model > L model > D-R model > F model. The models fitting degree of CO₂ adsorption in low permeability coal from high to low: optimized L model > optimized D-A model = optimized D-R model > D-A model > L model > D-R model > F model. The experimental results can provide geological basis for gas adsorption and CO₂ sequestration in low-permeability coal seams.