For the study of ship under large angle and high flow velocity and the collision response of large span cable-stayed bridge, Domestic and foreign relevant specifications for maximum impact force calculation method in ship bridge collision and impact was combined, in the process of inland waterway transport possible collision angle and the way was analyzed, and the outer ring of the Chongqing metro, Yangtze river bridge was taken as the project. The models of 7 000-ton bulk carrier and proportional cable-stayed bridge are established by using the additional mass method, and the maximum impact forces of forward collision, side collision and drift collision are calculated at four navigable water levels. The calculated values of each code are compared with the numerical simulation results, and the calculated results of each code under different conditions are compared. The results show that the domestic and foreign codes are more suitable for the ship impacting the bridge tower, and the maximum impact force is much higher than the calculated value of the code when the impact point is located at the bridge cap. In the case of a frontal collision between a ship and a bridge, the calculated values in AASHTO (American Association of State Highway and Transportation Officials) are in high agreement with the simulated values. In side impact, especially when the impact angle is 10° ~ 25°, it is suggested to adopt the Specifications for Collision Design of Highway Bridges. The impact force caused by the ship's floating collision with the bridge tower is about 1/4 of the forward collision, which can be calculated by the Code for Design of Railway Bridges and Culverts. The research results of multi-angle ship-bridge collision can provide reference for ship-bridge collision safety risk assessment and bridge anti-collision design under high fluctuating water level in the Three Gorges reservoir area.