The data of cultural and tourism resources are diverse, complex in format and difficult in storage and management. Therefore, it is imperative to prioritize the inheritance, protection and development of cultural tourism resources, and it is urgent to establish a data organization and management method. A comprehensive method for organizing and managing multiple cultural and tourism resource data was proposed based on GeoSOT grid subdivision theory. A detailed introduction was provided to the data overview of cultural and tourism resource, partitioning schemes, encoding schemes, retrieval mechanisms, and retrieval results. A database for cultural and tourism resources has been designed to effectively organize and manage various types of data encoded by GeoSOT. The results show that the GeoSOT-based grid is capable of effectively organizing and managing cultural and tourism resource data, enabling rapid data retrieval and meeting the management needs of cultural and tourism resource data.