In view of the phenomenon of waste of logistics volume caused by unreasonable workshop layout, a study was conducted on forging plants, and a single objective optimization function for minimizing logistics volume was established. The original layout was optimized using the systematic layout planning (SLP) method to obtain three layout plans. A combined weighting model was constructed using the analytic hierarchy process (AHP) and entropy weight method, Then, the technique for order preference by similarity to an ideal solution (TOPSIS) was used to rank and optimize the three options, forming a multi indicator decision evaluation model. Finally, the genetic algorithm was combined with the harmony search algorithm to perform secondary optimization on the layout of the forging plant workshop and obtain the optimal layout plan. The case study shows that this research method reduces the flow of goods by 28.82%, with significant improvement effects. At the same time, it also verifies the superiority of the model and provides certain reference value for workshop layout design in related industries.