基于相位相干图自编码器的阿尔茨海默病分类

刘宇轩 ,  魏静 ,  郭浩 ,  杨艳丽

科学技术与工程 ›› 2025, Vol. 25 ›› Issue (32) :13905-13914

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科学技术与工程 ›› 2025, Vol. 25 ›› Issue (32) :13905-13914 DOI: 10.12404/j.issn.1671-1815.2500509
自动化技术、计算机技术

基于相位相干图自编码器的阿尔茨海默病分类

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Classification of Alzheimer's Disease Based on Phase Coherence Graph Autoencoder

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摘要

传统主特征向量动力学分析(leading eigenvector dynamics analysis, LEiDA)在数据降维策略采用线性降维方法,忽略了大脑的非线性信息,同时在大脑状态识别使用k-means硬聚类方法,粗略的标准划分容易忽略一些非典型子状态及特征。针对这一问题,提出基于相位相干图自编码器(phase coherence graph autoencoder, PCGAE)分析方法。该方法利用PCGAE对大脑数据降维,并使用软硬聚类联合分析方法进行特征提取并对差异结果进行特征选择,最后利用支持向量机构建分类模型来检验分类效能。结果表明:所提方法在降维上具有更加优秀的聚类效应,并且在分类结果优于传统的LEiDA分类结果,达到83.7%。证明了该方法可以更好地进行动态功能模式分析和疾病分类。

Abstract

The traditional leading eigenvector dynamics analysis(LEiDA) employs linear dimensionality reduction methods, which overlook the nonlinear information of the brain. Additionally, the use of k-means hard clustering for brain state identification results in rough classifications, potentially neglecting atypical sub-states and features. To address this issue, the phase coherence graph autoencoder(PCGAE) analysis method was proposed. This method utilized the phase coherence graph autoencoder for dimensionality reduction, followed by the combined soft-hard clustering analysis method for feature extraction and differential feature selection. Finally, the support vector machine was used to build a classification model to evaluate classification performance. The results show that the proposed method achieves superior clustering effects in dimensionality reduction and outperforms traditional LEiDA classification results, with an accuracy of 83.7%. These findings suggest that the proposed method provides a better approach for dynamic functional pattern analysis and disease classification.

关键词

相位相干图自编码器(PCGAE) / 阿尔茨海默病 / 软硬聚类联合分析 / 静息态功能性磁共振成像(rs-fMRI) / 分类

Key words

phase coherence graph autoencoder(PCGAE) / Alzheimer's disease / combined soft-hard clustering analysis method / resting-state functional magnetic resonance imaging(rs-fMRI) / classification

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刘宇轩, 魏静, 郭浩, 杨艳丽. 基于相位相干图自编码器的阿尔茨海默病分类[J]. 科学技术与工程, 2025, 25(32): 13905-13914 DOI:10.12404/j.issn.1671-1815.2500509
LIU Yu-xuan, WEI Jing, GUO Hao, YANG Yan-li. Classification of Alzheimer's Disease Based on Phase Coherence Graph Autoencoder[J]. Science Technology and Engineering, 2025, 25(32): 13905-13914 DOI:10.12404/j.issn.1671-1815.2500509

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基金资助

山西省科技厅基础研究计划(20210302123129)

山西省科技厅基础研究计划青年项目(202203021222095)

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