为了精确表征受载状态下水合物储层渗透率的动态演化特征，以中国南海神狐海域泥质细粉砂水合物储层为研究目标，开展荷载条件下水合物试样渗透率实验研究，探究水合物填充和应力条件对水合物沉积物试样渗透率的作用机理及影响规律。结果表明：水合物沉积物试样的渗透率与水合物饱和度呈负相关，有效应力的增加会导致水合物沉积物试样的渗透率显著降低。水合物沉积物试样的渗透率对有效应力的敏感性随水合物饱和度的增加而降低。基于Masuda渗透率计算模型，考虑有效应力和水合物饱和度协同效应建立的修正的水合物渗透率变化模型具有一定的准确性，该模型具有较高的精度，能够更好地反映不同水合物饱和度在不同有效应力条件下的变化特征和规律。

To accurately characterize the dynamic evolution of hydrate reservoir permeability under loading conditions, clay-rich, fine-silty hydrate-bearing sediments from the Shenhu area of the South China Sea were investigated. A series of permeability tests were performed under controlled stress conditions to elucidate both the mechanisms and the governing effects of hydrate saturation and effective stress on sediment permeability. The results show that a negative correlation between permeability and hydrate saturation is observed, alongside a pronounced decrease in permeability with increasing effective stress. Moreover, the sensitivity of permeability to effective stress is found to diminish as hydrate saturation increased. Building upon the Masuda permeability calculation model, a modified model is developed to account for the synergistic influences of effective stress and hydrate saturation. This revised model provides high accuracy, offering a more reliable reflection of permeability variations and governing trends across different effective stress levels and hydrate saturations.