运用网络药理学分析脉络通颗粒治疗心绞痛的机制，并通过分子对接进行验证。在中药系统药理学平台TCMSP数据库中检索脉络通颗粒药物活性成分筛选靶基因；以“Angina Pectoris”为关键词在Genecards、OMIM数据库中检索疾病相关基因；将脉络通颗粒的活性成分靶点与心绞痛疾病靶点的交集作为关键靶点；利用STRING数据库构建蛋白互作网络（protein-protein interaction， PPI）；用Cytoscape 3．10．2软件构建脉络通颗粒-活性成分-潜在靶点网络；运用David数据库、微生信网站进行GO分析和KEGG富集分析。应用Pymol、AutoDock Tools等软件对核心成分与关键靶点进行分子对接的验证，并利用Pymol进行可视化分析。结果表明：脉络通颗粒有118个有效活性成分，544个靶点；心绞痛靶基因1 297个，药物-疾病共同基因176个，筛选血清半胱氨酸天冬氨酸蛋白酶-3（caspase-3, CASP3）、前列腺素内过氧化物合成酶2（prostaglandin-endoperoxide synthase 2, PTGS2）、血清基质金属蛋白酶9（matrix metalloproteinase 9, MMP9）、白介素-6（interleukin-6, IL-6）、肿瘤坏死因子（tumor necrosis factor, TNF）5个关键基因，GO功能富集分析和KEGG通路富集分析主要富集在糖基化终末产物-糖基化终末产物受体（advanced glycation end products-receptor of advanced glycation end products, AGE-RAGE）信号通路、流体剪切应力和动脉粥样硬化（fluid shear stress and atherosclerosis）等。将山柰酚（kaempferol）、柄花素（formononetin）、槲皮素（quercetin）、异鼠李素（isorhamnetin）、木犀草素（luteolin）分别作用于血清半胱氨酸天冬氨酸蛋白酶-3、前列腺素内过氧化物合成酶2、血清基质金属蛋白9、白介素-6、肿瘤坏死因子进行分子对接，结果显示木犀草素、山柰酚、异鼠李素、柄花素与CASP3、IL-6、PTGS2、TNF、MMP9均具有较强的结合活性。脉络通颗粒能够通过槲皮素、木犀草素等成分作用于血清半胱氨酸天冬氨酸蛋白酶-3、前列腺素内过氧化物合成酶2、血清基质金属蛋白酶9等核心靶点，调控流体剪切应力和动脉粥样硬化、AGE-RAGE信号通路等生物学途径，抑制内皮细胞增生，控制炎症反应，抗氧化应激，参与机体代谢治疗心绞痛。

To elucidate the mechanism of Mailuotong granules in treating angina pectoris through network pharmacology approaches and molecular docking validation. The TCMSP database of the Traditional Chinese Medicine Systems Pharmacology platform was searched for the target genes of the active ingredients in Mailuotong granules. The keywords "angina pectoris" were used to retrieve disease-related genes from the Genecards and OMIM databases. The intersection of Mailuotong granule's active ingredient targets and angina pectoris disease targets was identified as the key targets. PPI (protein-protein interaction) networks were constructed using the STRING database, while Cytoscape 3. 10. 2 software was utilized to build the network of "Mailuotong granules-active ingredients-potential targets." Functional enrichment analyses, including GO (gene ontology) and KEGG (kyoto encyclopedia of genes and genomes) pathway assessments, were performed through DAVID database and Weishengxin platform. Pymol, AutoDock Tools, and other software were used to verify the molecular docking between the core components and key targets, with Pymol also used for visual analysis. The results show that Mailuotong granules contained 118 active ingredients targeting 544 genes. There are 1 297 target genes associated with angina pectoris, with 176 common genes between the drug and the disease. Five key genes are screened: CASP3 (serum cysteine aspartate protease-3), PTGS2 (prostaglandin-endoperoxide synthase 2), MMP9 (matrix metalloproteinase-9), IL-6 (interleukin-6), and TNF (tumor necrosis factor). The biological pathways involve included AGE-RAGE, fluid shear stress, and atherosclerosis. Kaempferol, formononetin, quercetin, isorhamnetin, and luteolin are molecularly docked with CASP3, PTGS2, MMP9, IL-6, and TNF, respectively, demonstrating robust binding affinities. Mailuotong granules, through components such as quercetin and luteolin, can act on core targets like CASP3, PTGS2, and MMP9, regulate biological pathways such as fluid shear stress and atherosclerosis, and AGE-RAGE, inhibit endothelial cell proliferation, control inflammatory responses, combat oxidative stress, and participate in the body's metabolism in the treatment of angina pectoris.