为了探索香砂六君子汤干预高脂血症的潜在分子作用机制，通过运用网络药理学与分子对接技术，利用中药系统药理学技术平台（traditional Chinese medicine systemic pharmacology platform, TCMSP）收集香砂六君子汤化学活性成分及作用靶点，通过蛋白数据库、String数据库建立“成分-靶点”作用网络；基于筛选得到的靶点，对香砂六君子汤治疗的疾病高脂血症进行关联分析，建立“靶点-疾病”网络；随后进行基因本体（gene ontology analysis, GO）、京都基因与基因组百科全书（kyoto encyclopedia of genes and genomes, KEGG）、蛋白质互作网络（protein-protein interaction networks, PPI）富集分析得到香砂六君子汤治疗疾病的关键通路；得到的药物成分、靶点进行分子对接，综合探讨香砂六君子汤在临床上治疗高脂血症的复杂作用网络。结果表明：香砂六君子汤防治高脂血症的机制主要与晚期糖基化终产物-晚期糖基化终末产物受体（advanced glycation endproducts-receptor for advanced glycation endproducts, AGE-RAGE）信号通路、剪切应力与动脉粥样硬化（atherosclerosis, AS）通路、肿瘤坏死因子（tumor necrosis factor, TNF）通路、细胞凋亡通路有关；香砂六君子汤效应成分与高脂血症核心靶点结合度较好的代表性物质为黄芩素-ALOX12、川陈皮素-ALOX12。可见香砂六君子汤作为中药经典方剂具有良好的健脾降脂功效，探究其治疗高脂血症的作用机制对防治高脂血症具有重要意义。

In order to explore the potential molecular mechanism of Xiangsha Liujunzi Decoction in intervening hyperlipidaemia, the chemically active ingredients and targets of Xiangsha Liujunzi Decoction was collected using TCMSP (traditional Chinese medicine systemic pharmacology platform) by applying network pharmacology and molecular docking technology, and then the "ingredient-target" network was established through the protein database and String database. Based on the targets obtained from screening, the association analysis of hyperlipidaemia, a disease treated by Xiangsha Liujunzi Decoction, was carried out to establish a "target-disease" network; Subsequently, GO(gene ontology analysis), KEGG (kyoto encyclopedia of genes and genomes) and PPI(protein-protein Interaction networks) enrichment analysis was carried out to obtain the key pathways of Xiangsha Liujunzi Decoctionin the treatment of the disease; and the obtained components and targets were subjected to molecular docking, which resulted in the establishment of a 'target-disease' network. The obtained components and targets were subjected to molecular docking to comprehensively explore the complex action network of Xiangsha Liujunzi Decoction in the treatment of hyperlipidaemia in clinical practice. The results show that the mechanism of Xiangsha Liujunzi Decoction in preventing hyperlipidaemia is mainly related to the AGE-RAGE(advanced glycation endproducts-receptor for advanced glycation endproducts) signalling pathway, shear stress and AS(atherosclerosis) pathway, TNF(Tumor necrosis factor) pathway and apoptosis pathway, and that the effector components of Xiangsha Liujunzi Decoction has a better binding to the core targets of hyperlipidaemia, such as baicalein-ALOX12 and chuanchengpiin-ALOX12, which show that Xiangsha Liujunzi Decoction, as a classical Chinese medicine formula, has a good ability to strengthen the spleen and lower the blood pressure, and it is also a good choice for the treatment of hypertension. It can be seen that Xiangsha Liujunzi Decoction, as a classic traditional Chinese medicine formula, has good efficacy in strengthening the spleen and lowering lipids, and it is of great significance to investigate its mechanism of action in the treatment of hyperlipidaemia.