骨折联盟服务(FLS)对老年股骨粗隆间骨折患者功能预后及生存率的影响

柴利娟 ,  苗洁

科学技术与工程 ›› 2025, Vol. 25 ›› Issue (28) :11932-11937

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科学技术与工程 ›› 2025, Vol. 25 ›› Issue (28) :11932-11937 DOI: 10.12404/j.issn.1671-1815.2407074
医药、卫生

骨折联盟服务(FLS)对老年股骨粗隆间骨折患者功能预后及生存率的影响

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Impact of Fracture Liaison Service on Mobility and Mortality in Elderly Patients with Intertrochanteric Femur Fractures

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摘要

为了观察骨折联盟服务(fracture liaison service, FLS)模式对老年股骨粗隆间骨折患者术后活动能力及两年内死亡率的影响,回顾性分析2018年1月—2020年1月在邯郸市中心医院骨五科行手术治疗的大于60岁老年股骨粗隆间骨折的患者数据,比较未实施FLS组和实施FLS组术后的抗骨质疏松药物处方率、服药依从性、二次骨折发生率、功能性步行分级评定(functional ambulation classification, FAC)、Barthel指数、死亡率的差异。共122名患者纳入此研究:FLS实施前(A组)60名、FLS实施后(B组)62名。研究发现,抗骨质疏松药物处方率:B组(60,96.8%)高于A组(7,11.7%),P < 0.001;术后12个月时服药依从性:B组(7.29)高于A组(6.55),P < 0.001;术后两年发生二次骨折人数:B组2(3.2%)名患者和A组4(6.7%)名患者,P = 0.646;术后两年死亡率B组11名患者(18.3%)较A组低6名患者(9.7%),P = 0.217,差异均有统计学意义。术前两组Barthel指数评分差异无统计学意义;两组Barthel指数The评分12个月>6个月>1个月>术前,且组内两两比较差异有统计学意义。术前两组FAC评分差异无统计学意义;两组FAC评分12个月>6个月>1个月>术前,差异有统计学意义,且两两比较差异有统计学意义。综上,研究认为在FLS模式下给予老年股骨粗隆间骨折抗骨质疏松治疗,可以提高抗骨质疏松药物处方率、提高患者治疗依从性、降低二次脆性骨折的发生风险、提高术后活动能力、降低患者死亡率。

Abstract

To evaluate the effect of fracture liaison service (FLS) on postoperative mobility and 2-year mortality in elderly patients with intertrochanteric femur fractures. A retrospective cohort study was conducted including patients (≥ 60 years) who underwent surgical treatment for intertrochanteric fractures at Handan Central Hospital from January 2018 to January 2020. Participants were divided into pre-FLS (group A, n = 60) and post-FLS implementation (group B, n = 62) groups. Anti-osteoporotic drug prescription rates, medication adherence, re-fracture incidence, functional ambulation classification (FAC), Barthel index scores, and 2-year mortality were compared between groups. A significant increase in anti-osteoporotic drug prescription rates is observed in group B(96.8%) compared to group A (11.7%) (P < 0.001). Higher medication adherence is demonstrated in group B (7.29 ± 1.05) than in group A (6.55 ± 1.12) at 12 months postoperatively (P < 0.001). Within the 2-year follow-up, the re-fracture incidence is recorded as 3.2% (group B) versus 6.7% (group A) (P=0.646), while mortality rates are 9.7% (n = 6) in group B and 18.3%(n = 11) in group A (P = 0.217). Regarding functional recovery, progressive improvements in Barthel index and FAC scores are identified across all time points (12 months > 6 months > 1 month > preoperative; P < 0.05 for intra-group comparisons), with no significant inter-group differences detected at baseline. In summary, the implementation of FLS enhances anti-osteoporotic treatment compliance, improves postoperative mobility, and reduces mortality risk in elderly patients with intertrochanteric fractures. These findings support integrating FLS protocols into standard postoperative care.

关键词

骨折联盟服务(FLS) / 髋部骨折 / 死亡 / 骨质疏松 / 二次骨折

Key words

fracture liaison service(FLS) / hip fracture / mortality / osteoporosis / re-fracture

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柴利娟, 苗洁. 骨折联盟服务(FLS)对老年股骨粗隆间骨折患者功能预后及生存率的影响[J]. 科学技术与工程, 2025, 25(28): 11932-11937 DOI:10.12404/j.issn.1671-1815.2407074
CHAI Li-juan, MIAO Jie. Impact of Fracture Liaison Service on Mobility and Mortality in Elderly Patients with Intertrochanteric Femur Fractures[J]. Science Technology and Engineering, 2025, 25(28): 11932-11937 DOI:10.12404/j.issn.1671-1815.2407074

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