High-purity quartz is a key fundamental material for strategic emerging industries such as next-generation information technology and high-end equipment manufacturing. However, China''s high-end high-purity quartz raw materials have long been imported, posing severe challenges to resource security. Extensive highly fractionated leucogranites are hosted in the Northern Himalayan orogenic belt, and their quartz is characterized by relatively low lattice impurity content, which is shown to have great potential as a new type of high-purity quartz raw material. To evaluate the prospecting potential of high-purity quartz in this region, the Kudui garnet-bearing gneissic two-mica granite pluton on the northern side of the Kudui Dome in the Northern Himalayas was selected as the research object. Detailed analyses of petrological characteristics, inclusion features in quartz, occurrence states of impurity elements, and purification effects were conducted using polarizing microscopy, ICP-OES, and systematic mineral purification experiments. It is shown by the results that quartz in the Kudui pluton contains relatively few inclusions, mainly secondary fluid inclusions, which are easily removable by physico-chemical methods. After the purification process, the SiO? content in the quartz sand is determined to be 99.9958% (4N5 grade), approaching the international IOTA-STD high-purity quartz standard. The contents of major impurity elements, including Al (27.50×10??–27.65×10??), Ti (3.40×10??–3.45×10??), and Li (5.64×10??–5.66×10??), are found to be significantly low, which is closely related to the highly fractionated evolution of the magma. It is shown by analysis of impurity element occurrence states that the (Al3?+Fe3?+B3?)/(Na?+K?+Li?+P??) ratio in the purified samples is 1.08–1.09 (slightly greater than 1), indicating that trace amounts of impurities still exist as fine fluid or mineral inclusions. If the purification technology is improved to further remove alkali metal impurities such as Na, K, and Li from fluid or mineral inclusions, the quality can be further enhanced to above 4N6 grade. It is concluded from the study that the quartz raw material from the Kudui pluton is of excellent quality with great purification potential, meeting the quality requirements of mid-to-high-end high-purity quartz. It is confirmed by this discovery that the Northern Himalayan leucogranites possess the metallogenic potential to form large-scale high-purity quartz deposits, and this region is an important target area for seeking high-quality high-purity quartz resources.