The East Kunlun region, a significant metallogenic belt in China and an important metal ore cluster in Qinghai Province, has witnessed continuous progress in uranium exploration and research in recent years. The Xiaozaohuo uranium occurrence is located in the North Kunlun Composite Magmatic Arc. Preliminary exploration has delineated six ore bodies, with wall-rock alterations including silicification, hydromicazation, and hematitization. Pitchblende is the main primary uranium mineral, while autunite is the principal secondary uranium mineral. Granites are extensively distributed in study area, and ore bodies mainly occur in the Late Triassic porphyritic monzogranite and its contact zones. Nevertheless, the genetic link between granites and uranium mineralization remains ambiguous. In order to further determine the genetic type and source characteristics of the granites and the association with uranium mineralization in the area, the ore-hosting porphyritic monzogranite from the Xiaozaohuo uranium occurrence was selected for petrographic observation and geochemical analysis. The results indicate that the porphyritic monzogranite in the Xiaozaohuo area is geochemically characterized by high silica, relative potassium enrichment and sodium depletion. It is classified as a peraluminous high-K calc-alkaline granite, with geochemical affinities to S-type granites, and formed in a collisional to post-collisional tectonic setting. Porphyritic monzogranite is a product of partial melting of the crust, with the source region mainly consisting of greywacke. This granite has a high uranium content, making it an important uranium source for uranium mineralization in the area. The areas where porphyritic monzogranite and densely distributed fault structures occur, both within and around the study area, should be considered key prospecting targets for further exploration.