The Jiangwan area is situated within the Dadongshan Composite Pluton in the central segment of the Nanling Metallogenic Belt. Favorable geological conditions for uranium mineralization are developed in this area. However, low intensity of geophysical and geochemical exploration is presented in the region. Comprehensive prospecting criteria for both surface and deep uranium orebodies are not yet well established. This study is designed to comprehensively evaluate the uranium metallogenic potential of the peripheral area of the Jiangwan Deposit. The application effect of ground gamma-ray spectrometry and partial extraction geochemical prospecting survey in local uranium exploration is also assessed. A combined survey scheme of the two techniques was adopted in this study. Geophysical and geochemical anomalies in the intersection and clamping zone between the Chuandong Fault Bundle and F4-1 Fault Zone were mainly investigated. High spatial coincidence is shown between spectral uranium and sequential extraction uranium anomalies. Uranium mineralization information is directly reflected by both sets of anomalies. Uranium, beryllium and barium are identified as core prospecting indicators via cluster and correlation analysis. A uranium prospecting indicator assemblage for the study area is formed, with the comprehensive rare earth element enrichment index as a supplementary parameter. Through the integrated demonstration of multiple methods, the “source-migration-trapping” uranium metallogenic process in the study area has been preliminarily established.. One favorable uranium mineralization segment is delineated based on the comprehensive anomaly index. An industrial ore section with a cumulative thickness of 1.13 m was uncovered by trenching works.The effectiveness of this combined method is verified by field results. Scientific and reliable data support and technical basis for uranium exploration in the Dadongshan Composite Pluton are provided by these findings. Drilling verification is recommended to be prioritized at the intersection of the F13 and F4-1 Fault Zones.