Scoliosis is a common spinal deformity condition, and patients with different spinal deformities have different dynamic re- sponses in a whole-body vibration environment. The differences in the dynamic responses of Lenke 4C and Lenke 4C + spinal deformi- ties in the whole-body vibration environment were compared and analyzed. First, the finite element model of the ribs and the T1 ~ S1 segments of the thoracolumbosacral spine before and after surgery was established based on the scan images, and the validity of the model was verified. Then the modal, harmonic response and transient dynamics of the two finite element models were analyzed using the finite element software Abaqus. The comparative study revealed that the peak resonance of the Lenke 4C spinal deformity is general- ly higher than that of the Lenke 4C + spinal deformity. Under cyclic loading, the maximum von Mises stress in the annulus of fibers and the maximum pressure in the nucleus pulposus are generally higher in the Lenke 4C deformity than in the Lenke 4C deformity. Un- der cyclic loading with first- and second-order intrinsic frequencies, the displacement response of the Lenke 4C is greater than that of the Lenke 4C + deformity. Therefore, kyphosis significantly alters the dynamic response of the spine to external excitation, and the in- tervertebral discs in segments with larger deformities are more susceptible to injury. Lumbar intervertebral discs are subjected to greater stress and pressure in the whole-body vibration environment compared to thoracic intervertebral discs. The ribs have a greater influence on the vibration response of the spine model and should not be ignored. The results of the comparative study reveal the need for individ- ualized protection for scoliosis patients in order to prevent secondary injuries.