中医药干预氧化应激治疗IV型心肾综合征研究综述
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1.江西中医药大学;2.江西中医药大学附属医院

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R45

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国家自然科学(82260908)。


Review on Traditional Chinese Medicine Intervention for Oxidative Stress in the treatment of type IV Cardiorenal Syndrome
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1.Jiangxi University of Chinese Medicine;2.Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine

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    摘要:

    IV型心肾综合征,病变涉及心肾两脏,治疗时间长、费用高,死亡率高。现代研究表明, CRS 4 的发生发展与多种病理机制相关,而氧化应激在心脏、肾脏和其他系统中作用得到了广泛关注,研究CRS 4氧化应激作用机制具有重要意义。氧化应激调控CRS 4型的作用机制与Nrf2、NFkB 、JAK/STAT3以及JNK等信号通路有关,这些通路通过减少炎症反应,抑制心肾氧化应激反应,减少ROS的形成,防止内皮功能障碍,逆转左心室肥厚和心肾纤维。研究证实一些中药活性成分及复方具有抗氧化作用,可以通过减少ROS的形成,调控氧化应激通路,抑制IV型心肾综合征氧化应激反应的发生,从而发挥防治 CRS 4 的作用,但目前缺乏对该领域的系统性整理和归纳。因此,梳理了相关文献,分析阐释了中医药通过调控氧化应激防治CRS 4 的作用机制,以期为临床研究与药物开发提供新思路。

    Abstract:

    Type IV cardiorenal syndrome, with lesions involving the heart and kidney, has a long and costly treatment time and a high mortality rate. Modern studies have shown that the development of CRS 4 is associated with a variety of pathological mechanisms, and the role of oxidative stress in the heart, kidneys, and other systems has received widespread attention, so it is of great significance to study the mechanism of CRS 4 oxidative stress. The mechanism of action of oxidative stress-regulated CRS type 4 is related to signaling pathways such as Nrf2, NFkB , JAK/STAT3, and JNK, which prevent endothelial dysfunction by reducing inflammatory responses, inhibiting cardiac and renal oxidative stress, and preventing endothelial dysfunction by decreasing left ventricular hypertrophy and cardiorenal fibers.Studies have confirmed that some active ingredients and compound formulas of traditional Chinese medicine Possesses antioxidant effects.That can inhibit the occurrence of oxidative stress in cardiorenal syndrome type IV by reducing the formation of ROS and regulating the oxidative stress pathway, thus playing a role in preventing and controlling CRS 4. However, there is a lack of systematic collation and generalization in this field. Therefore, relevant literature was reviewed, and the mechanism of action by which traditional Chinese medicine regulates oxidative stress to prevent and treat CRS 4 was analyzed and elucidated, aiming to provide new insights for clinical research and drug development.

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袁文萋,刘庚鑫,张格第,等. 中医药干预氧化应激治疗IV型心肾综合征研究综述[J]. 科学技术与工程, , ():

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  • 收稿日期:2024-04-16
  • 最后修改日期:2024-05-11
  • 录用日期:2024-05-21
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