Land ecological security is the core of sustainable use of land resources, and land use change caused by human activities changes the structure and function of ecosystems, which has a serious impact on the regional ecological security system. In order to explore the changes of ecological security in Chongqing in recent years and 2030, this paper takes Chongqing as the research object and uses the PLUS model to simulate land use changes under the scenarios of natural development, ecological priority and development priority in 2030. Based on the P-S-R model, the ecological security evaluation index system was constructed, the index integration was carried out in combination with the mutation model, and the ecological security evaluation index of each year was calculated, and the proportion of ecological security above the general safety level in Chongqing from 2000 to 2020 showed a trend of "increase-decrease-increase-decrease". At the same time, the proportion of general safety level or above in the three scenarios was 85.25%, 89.88%, and 89.68%. The results show that the spatial pattern of ecological security in Chongqing is opposite to the spatial pattern of population density and GDP, and is consistent with the spatial pattern of natural data such as vegetation cover and slope, which indirectly indicates the impact of human activities on the ecological security pattern.