In order to solve the technical problem of insufficient reliability and life of rotary seal under the coupling effect of high pressure and high speed and medium corrosion, this paper carried out experimental research on rotary lip seal, designed and built a high-speed rotary lip seal test bed with pressure, carried out leakage and friction torque characteristic tests of lip seal, carried out simulation calculation of lip seal, and innovatively proposed a new type of seal with low friction coating. The temperature rise and torque comparison test of traditional seal and spraying new seal at different speeds were carried out. The experimental results show that the lip spraying PTFE material can effectively reduce the temperature rise of the seal. When the rotational speed increases by 1000 rpm, after reaching the heat balance temperature, the temperature rise of the spray lip seal is 2.4 °C lower than that of the traditional lip seal. Under the pressure condition, the temperature of the coated lip seal is about 3.48 °C lower than that of the traditional lip seal. Under the condition of high speed and poor lubrication, the temperature of the spray lip seal is about 4.61 °C lower than that of the traditional lip seal, but the sealing torque increases by about 0.03 N·m. In this paper, the sealing performance is evaluated from two aspects of sealing temperature rise and sealing friction torque, which provides theoretical support for solving the technical problems of high parameter rotary seal.