In order to solve the problem of difficulty in determining the optimal measurement points for bearing signal acquisition. Taking the NU306 bearing-housing system as the research object, the bearing housing to carry out multi-measurement points vibration test experiment. The local linear embedding algorithm is used to linearly reduce the multi-dimensional space data of the bearings to obtain the sensitivity matrix of the measurement point. The optimal position of the measuring point under varying load and rotation speed is studied when the inner or outer ring are defective. The results show that for bearings with outer ring failures, the optimal measurement point is the one closest to the location of the failure when the rotational speed increases, and the optimal measurement point is the one with the lowest structural stiffness on the bearing housing when the load increases. For bearings with inner ring failures, the optimal measurement point is the one at lower loads far from the centre of the housing when the load or rotational speed increases. The results of this paper can provide an effective reference for the selection of measurement points under different operating conditions.