In order to clarify the reservoir applicability of different acid systems, understand the influence of reservoir acid rock etching morphology on fracture conductivity, and give the optimal slug combination method for different horizons. Acid erosion fracture conductivity experiments were carried out in the carbonate reservoirs of Sichuan and Chongqing, the results show that the conductivity of slug combinations between different acid systems to the dolomite of the Maokou Formation after acid etching is higher than that of the limestone; the morphology of acid-etched fractures after acid-etching is different between different single-acid systems, in which steering acid has extremely deep grooves after etching, and the grooves of authigenic acid are the shallowest; for the Maokou Formation, the alternating grades of collodionic acid with fracking fluid and collodionic acid with authigenic acid are For the Qixia Formation and the Lampshade Formation, the highest inflow capacity is achieved when the alternation level between fracturing fluid and gel acid and gel acid and self-generated acid is three levels, and the inflow capacity of gel acid and self-generated acid can be up to 4.53 μm2·cm at 60 MPa after three levels of alternation; the highest inflow capacity of Qixia Formation and Lampshade Formation is achieved when the second level of alternation between fracturing fluid and gel acid is selected, and the inflow capacity is 6.72 μm2·cm and 7.47 μm2·cm at 60 MPa respectively.In the Sichuan Chongqing exploration area, on-site application and in-depth investigation were conducted to verify the acid corrosion fracture conductivity of the acid solution. The results showed that the acid corrosion effect was good after the acid solution entered the well, and the gas testing effect after the transformation was 208 × 104 m3/d, achieving the expected increase in production. It provides theoretical and experimental guidance for acid fracturing technology of carbonate reservoirs in Sichuan and Chongqing.