The problem of inaccurate evaluation of the clamping performance of the spiral angle type slip will be effectively overcome, which is caused by the unclear contact characteristics between the slip and the pipe string. In this paper, the forces acting on the interaction between slip and columns were analyzed by the theoretical method. A full-scale finite element model of the interaction between the slip, pipe column, and slip seat was established using the numerical simulation method. The mises stress and contact stress distribution patterns of the slip and pipe column under different axial loads and friction coefficients were studied. The mises stress and contact stress gradually decreases from the bottom to the top in the axial direction. They are an imperfect symmetric distribution in the circumferential direction. And there are stress concentration locations. The slip is subjected to higher mises stress and lower contact stress than the pipe column. As the axial load increases, the mises and contact stress increase. As the friction coefficient increases, the mises and contact stress decrease. In design and practical use, emphasis should be placed on components and locations with high-stress levels. Under high load conditions, increasing the friction coefficient by changing the material and shape of the slip teeth is recommended. Further the clamping performance of the slip under high load conditions is improved. It also prevents damage to the pipe column caused by excessive clamping force. The above results can provide theoretical guidance for the design of slips and the evaluation of clamping performance.